You might be tempted to use traditional methods for PC component cleaning, like copious amounts of isopropyl alcohol and compressed air, but you would be mistaken, according to Valve. What you should use to clean your Deck depends on which part you’re cleaning. To clean the display, Valve recommends wiping it with a clean, dry, microfiber cloth to avoid damaging the display or its coating. A wipe with a small amount of isopropyl alcohol on a dry cloth should suffice to clean any plastic surfaces.
The most important thing you’ll want to avoid when cleaning the Steam Deck is getting any liquids into the device, as this might cause problems with the electronics. This means you shouldn’t use isopropyl alcohol or any other liquid anywhere near any of the buttons or other input interfaces, especially near the rubberized thumbsticks, since alcohol can wreak all sorts of havoc on rubber. You should also only use 100% isopropyl alcohol when cleaning the Steam Deck since anything less will probably have a small amount of water in the mixture, which could damage any electrical components it comes into contact with (via Sunrise Industrial Cleaners).